miR-126-3p down-regulation contributes to dabrafenib acquired resistance in melanoma by up-regulating ADAM9 and VEGF-A

BACKGROUND: Development of resistance to inhibitors of BRAF (BRAFi) and MEK (MEKi) remains a great challenge for targeted therapy in patients with BRAF-mutant melanoma. Here, we explored the role of miRNAs in melanoma acquired resistance to BRAFi. METHODS: miRNA expression in two BRAF-mutant melanom...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Caporali, Simona, Amaro, Adriana, Levati, Lauretta, Alvino, Ester, Lacal, Pedro Miguel, Mastroeni, Simona, Ruffini, Federica, Bonmassar, Laura, Antonini Cappellini, Gian Carlo, Felli, Nadia, Carè, Alessandra, Pfeffer, Ulrich, D’Atri, Stefania
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6588909/
https://ncbi.nlm.nih.gov/pubmed/31227006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1238-4
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