Sensitizing Ewing sarcoma to chemo- and radiotherapy by inhibition of the DNA-repair enzymes DNA protein kinase (DNA-PK) and poly-ADP-ribose polymerase (PARP) 1/2

BACKGROUND: DNA-PK and PARP inhibitors sensitize cancer cells to chemo- and radiotherapy. ETS transcription factors (EWS-FLI1) have been described as biomarkers for PARP-inhibitor sensitivity. Sensitivity to single agent PARP inhibitors has so far been limited to homologous recombination repair (HRR...

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Udgivet i:Oncotarget
Main Authors: Vormoor, Britta, Schlosser, Yvonne T., Blair, Helen, Sharma, Abhishek, Wilkinson, Sarah, Newell, David R., Curtin, Nicola
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5768336/
https://ncbi.nlm.nih.gov/pubmed/29371919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21300
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