Combining poly(ADP-ribose) polymerase 1 (PARP-1) inhibition and radiation in Ewing sarcoma results in lethal DNA damage

Ewing sarcomas (ES) harbor a chromosomal translocation that fuses the EWS gene to an ETS transcription factor, most commonly FLI1. The EWS-FLI1 fusion acts in a positive feedback loop to maintain expression of poly(ADP-ribose) polymerase 1 (PARP-1), which is involved in repair of DNA damage. Here, w...

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Main Authors: Lee, Hae-June, Yoon, Changhwan, Schmidt, Benjamin, Park, Do Joong, Zhang, Alexia Y., Erkizan, Hayriye V., Toretsky, Jeffrey A., Kirsch, David G., Yoon, Sam S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3823674/
https://ncbi.nlm.nih.gov/pubmed/23966622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-13-0338
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