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Formation of S-[2-(N(6)-Deoxyadenosinyl)ethyl]glutathione in DNA and Replication Past the Adduct by Translesion DNA Polymerases
1,2-Dibromoethane (DBE, ethylene dibromide) is a potent carcinogen due at least in part to its DNA crosslinking effects. DBE crosslinks glutathione (GSH) to DNA, notably to sites on 2´-deoxyadenosine and 2´-deoxyguanosine (Cmarik, J. L. et al. (1991) J. Biol. Chem. 267, 6672–6679). Adduction at the...
Gorde:
| Argitaratua izan da: | Chem Res Toxicol |
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| Egile Nagusiak: | , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2017
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5768145/ https://ncbi.nlm.nih.gov/pubmed/28395138 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.7b00022 |
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