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Evidence for formation of an S-[2-(N7-guanyl)ethyl]glutathione adduct in glutathione-mediated binding of the carcinogen 1,2-dibromoethane to DNA.
The carcinogen 1,2-dibromoethane and reduced glutathione (GSH) were irreversibly bound to calf thymus DNA in equimolar amounts when in vitro incubations were carried out in the presence of GSH S-transferase. In studies carried out with isolated hepatocytes, equimolar amounts of 1,2-dibromoethane and...
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| Gepubliceerd in: | Proc Natl Acad Sci U S A |
|---|---|
| Hoofdauteurs: | , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
National Academy of Sciences
1983
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC384234/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6577422/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.80.17.5266 |
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