Engineering of a DNA Polymerase for Direct m(6)A Sequencing

Methods for the detection of RNA modifications are of fundamental importance for advancing epitranscriptomics. N (6)‐methyladenosine (m(6)A) is the most abundant RNA modification in mammalian mRNA and is involved in the regulation of gene expression. Current detection techniques are laborious and re...

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Dettagli Bibliografici
Pubblicato in:Angew Chem Int Ed Engl
Autori principali: Aschenbrenner, Joos, Werner, Stephan, Marchand, Virginie, Adam, Martina, Motorin, Yuri, Helm, Mark, Marx, Andreas
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2017
Soggetti:
Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5768020/
https://ncbi.nlm.nih.gov/pubmed/29115744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201710209
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