The effect of an adenosine A(2A) agonist on intra-tumoral concentrations of temozolomide in patients with recurrent glioblastoma

BACKGROUND: The blood–brain barrier (BBB) severely limits the entry of systemically administered drugs including chemotherapy to the brain. In rodents, regadenoson activation of adenosine A(2A) receptors causes transient BBB disruption and increased drug concentrations in normal brain. This study wa...

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Bibliografische gegevens
Gepubliceerd in:Fluids Barriers CNS
Hoofdauteurs: Jackson, Sadhana, Weingart, Jon, Nduom, Edjah K., Harfi, Thura T., George, Richard T., McAreavey, Dorothea, Ye, Xiaobu, Anders, Nicole M., Peer, Cody, Figg, William D., Gilbert, Mark, Rudek, Michelle A., Grossman, Stuart A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2018
Onderwerpen:
Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767971/
https://ncbi.nlm.nih.gov/pubmed/29332604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12987-017-0088-8
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