ACTR-85. THE EFFECT OF REGADENOSON ON TEMOZOLOMIDE NEUROPHARMACOKINETICS IN GLIOBLASTOMA PATIENTS MEASURED BY INTRACEREBRAL MICRODIALYSIS

PURPOSE: The blood-brain barrier (BBB) prevents effective delivery of systemic therapy to the brain. Activation of A(2A) adenosine receptor by regadenoson has demonstrated transient BBB disruption in animals, allowing dextran (70kD) brain entry and increased temozolomide delivery. Temozolomide is th...

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Gepubliceerd in:Neuro Oncol
Hoofdauteurs: Jackson, Sadhana, Weingart, Jon, Nduom, Edjah, Holdhoff, Matthias, Blakeley, Jashri, Piotrowski, Anna F, Abd, Thura, George, Richard, McAreavey, Dorothea, Ye, Xiaobu, Anders, Nicole, Peer, Cody, Barnes, Julie, Figg, William, Rudek, Michelle, Gilbert, Mark, Grossman, Stuart A
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5691878/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.071
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