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The effect of regadenoson-induced transient disruption of the blood–brain barrier on temozolomide delivery to normal rat brain
The blood–brain barrier (BBB) significantly reduces the delivery of many systemically administered agents to the central nervous system. Although temozolomide is the only chemotherapy to improve survival in patients with glioblastoma, its concentration in brain is only 20 % of that in blood. Regaden...
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| Publicado no: | J Neurooncol |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4733584/ https://ncbi.nlm.nih.gov/pubmed/26626489 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-015-1998-4 |
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