The effect of regadenoson-induced transient disruption of the blood–brain barrier on temozolomide delivery to normal rat brain

The blood–brain barrier (BBB) significantly reduces the delivery of many systemically administered agents to the central nervous system. Although temozolomide is the only chemotherapy to improve survival in patients with glioblastoma, its concentration in brain is only 20 % of that in blood. Regaden...

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Veröffentlicht in:J Neurooncol
Hauptverfasser: Jackson, Sadhana, Anders, Nicole M., Mangraviti, Antonella, Wanjiku, Teresia M., Sankey, Eric W., Liu, Ann, Brem, Henry, Tyler, Betty, Rudek, Michelle A., Grossman, Stuart A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4733584/
https://ncbi.nlm.nih.gov/pubmed/26626489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-015-1998-4
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