The effect of an adenosine A(2A) agonist on intra-tumoral concentrations of temozolomide in patients with recurrent glioblastoma

BACKGROUND: The blood–brain barrier (BBB) severely limits the entry of systemically administered drugs including chemotherapy to the brain. In rodents, regadenoson activation of adenosine A(2A) receptors causes transient BBB disruption and increased drug concentrations in normal brain. This study wa...

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Detalhes bibliográficos
Publicado no:Fluids Barriers CNS
Main Authors: Jackson, Sadhana, Weingart, Jon, Nduom, Edjah K., Harfi, Thura T., George, Richard T., McAreavey, Dorothea, Ye, Xiaobu, Anders, Nicole M., Peer, Cody, Figg, William D., Gilbert, Mark, Rudek, Michelle A., Grossman, Stuart A.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767971/
https://ncbi.nlm.nih.gov/pubmed/29332604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12987-017-0088-8
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