Quantitative ligand and receptor binding studies reveal the mechanism of interleukin-36 (IL-36) pathway activation

IL-36 cytokines signal through the IL-36 receptor (IL-36R) and a shared subunit, IL-1RAcP (IL-1 receptor accessory protein). The activation mechanism for the IL-36 pathway is proposed to be similar to that of IL-1 in that an IL-36R agonist (IL-36α, IL-36β, or IL-36γ) forms a binary complex with IL-3...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Zhou, Li, Todorovic, Viktor, Kakavas, Steve, Sielaff, Bernhard, Medina, Limary, Wang, Leyu, Sadhukhan, Ramkrishna, Stockmann, Henning, Richardson, Paul L., DiGiammarino, Enrico, Sun, Chaohong, Scott, Victoria
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767850/
https://ncbi.nlm.nih.gov/pubmed/29180446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.805739
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