Mitochondrial intermediate peptidase is a novel regulator of sirtuin‐3 activation by caloric restriction

Sirtuin‐3 (SIRT3) regulates mitochondrial quality and is involved in the anti‐ageing and pro‐longevity actions of caloric restriction (CR). Here, we show that CR upregulates the mature form of SIRT3 and mitochondrial intermediate peptidase (MIPEP), a mitochondrial signal peptidase (MtSPase), in whit...

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Veröffentlicht in:FEBS Lett
Hauptverfasser: Kobayashi, Masaki, Takeda, Kanae, Narita, Takumi, Nagai, Keita, Okita, Naoyuki, Sudo, Yuka, Miura, Yuri, Tsumoto, Hiroki, Nakagawa, Yoshimi, Shimano, Hitoshi, Higami, Yoshikazu
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
Schlagworte:
Research Letters
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767765/
https://ncbi.nlm.nih.gov/pubmed/29151261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.12914
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