A High‐Resolution Crystal Structure that Reveals Molecular Details of Target Recognition by the Calcium‐Dependent Lipopeptide Antibiotic Laspartomycin C

The calcium‐dependent antibiotics (CDAs) are an important emerging class of antibiotics. The crystal structure of the CDA laspartomycin C in complex with calcium and the ligand geranyl‐phosphate at a resolution of 1.28 Å is reported. This is the first crystal structure of a CDA bound to its bacteria...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Kleijn, Laurens H. J., Vlieg, Hedwich C., Wood, Thomas M., Sastre Toraño, Javier, Janssen, Bert J. C., Martin, Nathaniel I.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767759/
https://ncbi.nlm.nih.gov/pubmed/29108098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201709240
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