Inactivation of the Lipopeptide Antibiotic Daptomycin by Hydrolytic Mechanisms

The lipopeptide daptomycin is a member of the newest FDA-approved antimicrobial class, exhibiting potency against a broad range of Gram-positive pathogens with only rare incidences of clinical resistance. Environmental bacteria harbor an abundance of resistance determinants orthologous to those in p...

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Main Authors: D'Costa, Vanessa M., Mukhtar, Tariq A., Patel, Tejal, Koteva, Kalinka, Waglechner, Nicholas, Hughes, Donald W., Wright, Gerard D., De Pascale, Gianfranco
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2012
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3264212/
https://ncbi.nlm.nih.gov/pubmed/22083474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05441-11
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