P2X7 Nucleotide and EGF Receptors Exert Dual Modulation of the Dual-Specificity Phosphatase 6 (MKP-3) in Granule Neurons and Astrocytes, Contributing to Negative Feedback on ERK Signaling

Extracellular signal-regulated kinases 1 and 2 (ERK1/2) play a central role in the intracellular signaling of P2X7 nucleotide receptors in neurons and glial cells. Fine spatio-temporal tuning of mitogen-activated protein (MAP) kinases is essential to regulate their biological activity. MAP kinase ph...

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Detalles Bibliográficos
Publicado en:Front Mol Neurosci
Autores principales: Queipo, Mª José, Gil-Redondo, Juan C., Morente, Verónica, Ortega, Felipe, Miras-Portugal, Mª Teresa, Delicado, Esmerilda G., Pérez-Sen, Raquel
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767727/
https://ncbi.nlm.nih.gov/pubmed/29375309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2017.00448
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