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P2X7, NMDA and BDNF receptors converge on GSK3 phosphorylation and cooperate to promote survival in cerebellar granule neurons

Glycogen synthase kinase-3 (GSK3) is a key player in the regulation of neuronal survival. Herein, we report evidence of an interaction between P2X7 receptors with NMDA and BDNF receptors at the level of GSK3 signalling and neuroprotection. The activation of these receptors in granule neurons led to...

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Detalhes bibliográficos
Main Authors: Ortega, Felipe, Pérez-Sen, Raquel, Morente, Verónica, Delicado, Esmerilda G., Miras-Portugal, Maria Teresa
Formato: Artigo
Idioma:Inglês
Publicado em: SP Birkhäuser Verlag Basel 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858808/
https://ncbi.nlm.nih.gov/pubmed/20146080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-010-0278-x
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