N-Ethylmaleimide increases KCC2 cotransporter activity by modulating transporter phosphorylation

K(+)/Cl(−) cotransporter 2 (KCC2) is selectively expressed in the adult nervous system and allows neurons to maintain low intracellular Cl(−) levels. Thus, KCC2 activity is an essential prerequisite for fast hyperpolarizing synaptic inhibition mediated by type A γ-aminobutyric acid (GABA(A)) recepto...

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Библиографические подробности
Опубликовано в: :J Biol Chem
Главные авторы: Conway, Leslie C., Cardarelli, Ross A., Moore, Yvonne E., Jones, Karen, McWilliams, Lisa J., Baker, David J., Burnham, Matthew P., Bürli, Roland W., Wang, Qi, Brandon, Nicholas J., Moss, Stephen J., Deeb, Tarek Z.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2017
Предметы:
Neurobiology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766942/
https://ncbi.nlm.nih.gov/pubmed/29092909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.817841
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