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Reducing the Levels of Akt Activation by PDK1 Knock-in Mutation Protects Neuronal Cultures against Synthetic Amyloid-Beta Peptides

The Akt kinase has been widely assumed for years as a key downstream effector of the PI3K signaling pathway in promoting neuronal survival. This notion was however challenged by the finding that neuronal survival responses were still preserved in mice with reduced Akt activity. Moreover, here we sho...

詳細記述

保存先:
書誌詳細
出版年:Front Aging Neurosci
主要な著者: Yang, Shaobin, Pascual-Guiral, Sònia, Ponce, Rebeca, Giménez-Llort, Lydia, Baltrons, María A., Arancio, Ottavio, Palacio, Jose R., Clos, Victoria M., Yuste, Victor J., Bayascas, Jose R.
フォーマット: Artigo
言語:Inglês
出版事項: Frontiers Media S.A. 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766684/
https://ncbi.nlm.nih.gov/pubmed/29358916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2017.00435
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