Interaction of PDK1 with Phosphoinositides Is Essential for Neuronal Differentiation but Dispensable for Neuronal Survival

3-Phosphoinositide-dependent protein kinase 1 (PDK1) operates in cells in response to phosphoinositide 3-kinase activation and phosphatidylinositol-3,4,5-trisphosphate [PtdIns(3,4,5)P(3)] production by activating a number of AGC kinases, including protein kinase B (PKB)/Akt. Both PDK1 and PKB contai...

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Detalhes bibliográficos
Main Authors: Zurashvili, Tinatin, Cordón-Barris, Lluís, Ruiz-Babot, Gerard, Zhou, Xiangyu, Lizcano, Jose M., Gómez, Nestor, Giménez-Llort, Lydia, Bayascas, Jose R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3623085/
https://ncbi.nlm.nih.gov/pubmed/23275438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01052-12
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