Reducing the Levels of Akt Activation by PDK1 Knock-in Mutation Protects Neuronal Cultures against Synthetic Amyloid-Beta Peptides

The Akt kinase has been widely assumed for years as a key downstream effector of the PI3K signaling pathway in promoting neuronal survival. This notion was however challenged by the finding that neuronal survival responses were still preserved in mice with reduced Akt activity. Moreover, here we sho...

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Detaylı Bibliyografya
Yayımlandı:Front Aging Neurosci
Asıl Yazarlar: Yang, Shaobin, Pascual-Guiral, Sònia, Ponce, Rebeca, Giménez-Llort, Lydia, Baltrons, María A., Arancio, Ottavio, Palacio, Jose R., Clos, Victoria M., Yuste, Victor J., Bayascas, Jose R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2018
Konular:
Neuroscience
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766684/
https://ncbi.nlm.nih.gov/pubmed/29358916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2017.00435
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