Reducing the Levels of Akt Activation by PDK1 Knock-in Mutation Protects Neuronal Cultures against Synthetic Amyloid-Beta Peptides

The Akt kinase has been widely assumed for years as a key downstream effector of the PI3K signaling pathway in promoting neuronal survival. This notion was however challenged by the finding that neuronal survival responses were still preserved in mice with reduced Akt activity. Moreover, here we sho...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Front Aging Neurosci
Main Authors: Yang, Shaobin, Pascual-Guiral, Sònia, Ponce, Rebeca, Giménez-Llort, Lydia, Baltrons, María A., Arancio, Ottavio, Palacio, Jose R., Clos, Victoria M., Yuste, Victor J., Bayascas, Jose R.
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2018
Assuntos:
Neuroscience
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766684/
https://ncbi.nlm.nih.gov/pubmed/29358916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2017.00435
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares