Distinct modulation of inactivation by a residue in the pore domain of voltage-gated Na(+) channels: mechanistic insights from recent crystal structures

Inactivation of voltage-gated Na(+) channels (VGSC) is essential for the regulation of cellular excitability. The molecular rearrangement underlying inactivation is thought to involve the intracellular linker between domains III and IV serving as inactivation lid, the receptor for the lid (domain II...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Cervenka, Rene, Lukacs, Peter, Gawali, Vaibhavkumar S., Ke, Song, Koenig, Xaver, Rubi, Lena, Zarrabi, Touran, Hilber, Karlheinz, Sandtner, Walter, Stary-Weinzinger, Anna, Todt, Hannes
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766632/
https://ncbi.nlm.nih.gov/pubmed/29330525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18919-1
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