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Distinct modulation of inactivation by a residue in the pore domain of voltage-gated Na(+) channels: mechanistic insights from recent crystal structures

Inactivation of voltage-gated Na(+) channels (VGSC) is essential for the regulation of cellular excitability. The molecular rearrangement underlying inactivation is thought to involve the intracellular linker between domains III and IV serving as inactivation lid, the receptor for the lid (domain II...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Cervenka, Rene, Lukacs, Peter, Gawali, Vaibhavkumar S., Ke, Song, Koenig, Xaver, Rubi, Lena, Zarrabi, Touran, Hilber, Karlheinz, Sandtner, Walter, Stary-Weinzinger, Anna, Todt, Hannes
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766632/
https://ncbi.nlm.nih.gov/pubmed/29330525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18919-1
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