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Exploring the Structure of the Voltage-gated Na(+) Channel by an Engineered Drug Access Pathway to the Receptor Site for Local Anesthetics
Despite the availability of several crystal structures of bacterial voltage-gated Na(+) channels, the structure of eukaryotic Na(+) channels is still undefined. We used predictions from available homology models and crystal structures to modulate an external access pathway for the membrane-impermean...
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| Glavni autori: | , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2014
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4118135/ https://ncbi.nlm.nih.gov/pubmed/24947510 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.541763 |
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