Over-expression of a retinol dehydrogenase (SRP35/DHRS7C) in skeletal muscle activates mTORC2, enhances glucose metabolism and muscle performance

SRP-35 is a short-chain dehydrogenase/reductase belonging to the DHRS7C dehydrogenase/ reductase family 7. Here we show that its over-expression in mouse skeletal muscles induces enhanced muscle performance in vivo, which is not related to alterations in excitation-contraction coupling but rather li...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Ruiz, Alexis, Dror, Erez, Handschin, Christoph, Furrer, Regula, Perez-Schindler, Joaquin, Bachmann, Christoph, Treves, Susan, Zorzato, Francesco
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766524/
https://ncbi.nlm.nih.gov/pubmed/29330505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18844-3
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