Targeted reconstruction of T cell receptor sequence from single cell RNA-seq links CDR3 length to T cell differentiation state

The T cell compartment must contain diversity in both T cell receptor (TCR) repertoire and cell state to provide effective immunity against pathogens. However, it remains unclear how differences in the TCR contribute to heterogeneity in T cell state. Single cell RNA-sequencing (scRNA-seq) can allow...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Afik, Shaked, Yates, Kathleen B., Bi, Kevin, Darko, Samuel, Godec, Jernej, Gerdemann, Ulrike, Swadling, Leo, Douek, Daniel C., Klenerman, Paul, Barnes, Eleanor J., Sharpe, Arlene H., Haining, W. Nicholas, Yosef, Nir
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
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Methods Online
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766189/
https://ncbi.nlm.nih.gov/pubmed/28934479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx615
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