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Probing Ligand Exchange in the P450 Enzyme CYP121 from Mycobacterium tuberculosis: Dynamic Equilibrium of the Distal Heme Ligand as a Function of pH and Temperature

CYP121 is a cytochrome P450 enzyme from Mycobacterium tuberculosis that catalyzes the formation of a C–C bond between the aromatic groups of its cyclodityrosine substrate (cYY). The crystal structure of CYP121 in complex with cYY reveals that the solvent-derived ligand remains bound to the ferric io...

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Bibliografske podrobnosti
izdano v:J Am Chem Soc
Main Authors: Fielding, Andrew J., Dornevil, Kednerlin, Ma, Li, Davis, Ian, Liu, Aimin
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5765751/
https://ncbi.nlm.nih.gov/pubmed/29090577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b08911
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