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Investigations of heme ligation and ligand switching in cytochromes P450 and P420
It is generally accepted that the inactive P420 form of cytochrome P450 (CYP) involves the protonation of the native cysteine thiolate to form a neutral thiol heme ligand. On the other hand, it has also been suggested that recruitment of a histidine to replace the native cysteine thiolate ligand mig...
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3777526/ https://ncbi.nlm.nih.gov/pubmed/23905516 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400541v |
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