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WT1 peptide vaccine in Montanide in contrast to poly ICLC, is able to induce WT1-specific immune response with TCR clonal enrichment in myeloid leukemia
BACKGROUND: The optimal strategy for vaccination to induce CD8(+) T cell responses against WT1 is not known. METHODS: A pilot randomized study in HLA-A02(+) patients to receive vaccination with WT1 in Montanide or in poly ICLC, a TLR3 agonist, to explore the novel immune adjuvant was conducted. Seve...
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Publicado no: | Exp Hematol Oncol |
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Main Authors: | , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
BioMed Central
2018
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5765712/ https://ncbi.nlm.nih.gov/pubmed/29344432 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40164-018-0093-x |
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