CUG initiation and frameshifting enable production of dipeptide repeat proteins from ALS/FTD C9ORF72 transcripts

Expansion of G(4)C(2) repeats in the C9ORF72 gene is the most prevalent inherited form of amyotrophic lateral sclerosis and frontotemporal dementia. Expanded transcripts undergo repeat-associated non-AUG (RAN) translation producing dipeptide repeat proteins from all reading frames. We determined cis...

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Udgivet i:Nat Commun
Main Authors: Tabet, Ricardos, Schaeffer, Laure, Freyermuth, Fernande, Jambeau, Melanie, Workman, Michael, Lee, Chao-Zong, Lin, Chun-Chia, Jiang, Jie, Jansen-West, Karen, Abou-Hamdan, Hussein, Désaubry, Laurent, Gendron, Tania, Petrucelli, Leonard, Martin, Franck, Lagier-Tourenne, Clotilde
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5764992/
https://ncbi.nlm.nih.gov/pubmed/29323119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02643-5
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