Calmodulin fishing with a structurally disordered bait triggers CyaA catalysis

Once translocated into the cytosol of target cells, the catalytic domain (AC) of the adenylate cyclase toxin (CyaA), a major virulence factor of Bordetella pertussis, is potently activated by binding calmodulin (CaM) to produce supraphysiological levels of cAMP, inducing cell death. Using a combinat...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: O’Brien, Darragh P., Durand, Dominique, Voegele, Alexis, Hourdel, Véronique, Davi, Marilyne, Chamot-Rooke, Julia, Vachette, Patrice, Brier, Sébastien, Ladant, Daniel, Chenal, Alexandre
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5764468/
https://ncbi.nlm.nih.gov/pubmed/29287065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2004486
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