Neutrophil elastase enhances antigen presentation by upregulating human leukocyte antigen class I expression on tumor cells

Neutrophil elastase (NE) is an innate immune cell-derived inflammatory mediator that we have shown increases the presentation of tumor-associated peptide antigens in breast cancer. In this study, we extend these observations to show that NE uptake has a broad effect on enhancing antigen presentation...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Immunother
Main Authors: Chawla, Akhil, Alatrash, Gheath, Philips, Anne V., Qiao, Na, Sukhumalchandra, Pariya, Kerros, Celine, Diaconu, Iulia, Gall, Victor, Neal, Samantha, Peters, Haley L., Clise-Dwyer, Karen, Molldrem, Jeffrey J., Mittendorf, Elizabeth A.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5764112/
https://ncbi.nlm.nih.gov/pubmed/27129972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-016-1841-6
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