Neuropilin-1 mediates neutrophil elastase uptake and cross-presentation in breast cancer cells

Neutrophil elastase (NE) can be rapidly taken up by tumor cells that lack endogenous NE expression, including breast cancer, which results in cross-presentation of PR1, an NE-derived HLA-A2-restricted peptide that is an immunotherapy target in hematological and solid tumor malignancies. The mechanis...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Kerros, Celine, Tripathi, Satyendra C., Zha, Dongxing, Mehrens, Jennifer M., Sergeeva, Anna, Philips, Anne V., Qiao, Na, Peters, Haley L., Katayama, Hiroyuki, Sukhumalchandra, Pariya, Ruisaard, Kathryn E., Perakis, Alexander A., St. John, Lisa S., Lu, Sijie, Mittendorf, Elizabeth A., Clise-Dwyer, Karen, Herrmann, Amanda C., Alatrash, Gheath, Toniatti, Carlo, Hanash, Samir M., Ma, Qing, Molldrem, Jeffrey J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2017
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5473232/
https://ncbi.nlm.nih.gov/pubmed/28468826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.773051
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge