Fucosylation Enhances the Efficacy of Adoptively Transferred Antigen-specific Cytotoxic T Lymphocytes

PURPOSE: Inefficient homing of adoptively transferred cytotoxic T lymphocytes (CTLs) to tumors is a major limitation to the efficacy of adoptive cellular therapy (ACT) for cancer. However, through fucosylation, a process whereby fucosyltransferases (FTs) add fucose groups to cell surface glycoprotei...

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Publicado no:Clin Cancer Res
Main Authors: Alatrash, Gheath, Qiao, Na, Zhang, Mao, Zope, Madhushree, Perakis, Alexander A., Sukhumalchandra, Pariya, Philips, Anne V., Garber, Haven R., Kerros, Celine, John, Lisa S. St., Khouri, Maria R., Khong, Hiep, Clise-Dwyer, Karen, Miller, Leonard P., Wolpe, Steve, Overwijk, Willem W., Molldrem, Jeffrey J., Ma, Qing, Shpall, Elizabeth J., Mittendorf, Elizabeth A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6467811/
https://ncbi.nlm.nih.gov/pubmed/30647079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-1527
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