Type I IFN signature in childhood-onset systemic lupus erythematosus: a conspiracy of DNA- and RNA-sensing receptors?

BACKGROUND: Childhood-onset systemic lupus erythematosus (cSLE) is an incurable multi-systemic autoimmune disease. Interferon type I (IFN-I) plays a pivotal role in the pathogenesis of SLE. The objective of this study was to assess the prevalence of the IFN-I signature and the contribution of cytoso...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Wahadat, M. Javad, Bodewes, Iris L. A., Maria, Naomi I., van Helden-Meeuwsen, Cornelia G., van Dijk-Hummelman, Annette, Steenwijk, Eline C., Kamphuis, Sylvia, Versnel, Marjan A.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5763828/
https://ncbi.nlm.nih.gov/pubmed/29321042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-017-1501-z
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