PAXX and Xlf interplay revealed by impaired CNS development and immunodeficiency of double KO mice

The repair of DNA double-stranded breaks (DNAdsb) through non-homologous end joining (NHEJ) is a prerequisite for the proper development of the central nervous system and the adaptive immune system. Yet, mice with Xlf or PAXX loss of function are viable and present with very mild immune phenotypes,...

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Опубликовано в: :Cell Death Differ
Главные авторы: Abramowski, Vincent, Etienne, Olivier, Elsaid, Ramy, Yang, Junjie, Berland, Aurélie, Kermasson, Laetitia, Roch, Benoit, Musilli, Stefania, Moussu, Jean-Paul, Lipson-Ruffert, Karelia, Revy, Patrick, Cumano, Ana, Boussin, François D, de Villartay, Jean-Pierre
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2018
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Original Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5762856/
https://ncbi.nlm.nih.gov/pubmed/29077092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.184
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