PAXX and Xlf interplay revealed by impaired CNS development and immunodeficiency of double KO mice

The repair of DNA double-stranded breaks (DNAdsb) through non-homologous end joining (NHEJ) is a prerequisite for the proper development of the central nervous system and the adaptive immune system. Yet, mice with Xlf or PAXX loss of function are viable and present with very mild immune phenotypes,...

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Detaylı Bibliyografya
Yayımlandı:Cell Death Differ
Asıl Yazarlar: Abramowski, Vincent, Etienne, Olivier, Elsaid, Ramy, Yang, Junjie, Berland, Aurélie, Kermasson, Laetitia, Roch, Benoit, Musilli, Stefania, Moussu, Jean-Paul, Lipson-Ruffert, Karelia, Revy, Patrick, Cumano, Ana, Boussin, François D, de Villartay, Jean-Pierre
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2018
Konular:
Original Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5762856/
https://ncbi.nlm.nih.gov/pubmed/29077092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.184
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