The peroxisomal AAA-ATPase Pex1/Pex6 unfolds substrates by processive threading

Pex1 and Pex6 form a heterohexameric motor essential for peroxisome biogenesis and function, and mutations in these AAA-ATPases cause most peroxisome-biogenesis disorders in humans. The tail-anchored protein Pex15 recruits Pex1/Pex6 to the peroxisomal membrane, where it performs an unknown function...

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Udgivet i:Nat Commun
Main Authors: Gardner, Brooke M., Castanzo, Dominic T., Chowdhury, Saikat, Stjepanovic, Goran, Stefely, Matthew S., Hurley, James H., Lander, Gabriel C., Martin, Andreas
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5762779/
https://ncbi.nlm.nih.gov/pubmed/29321502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02474-4
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