Reduced FBXW7 expression in pancreatic cancer correlates with poor prognosis and chemotherapeutic resistance via accumulation of MCL1

Pancreatic cancer is a highly malignant tumor type with poor outcomes, and elucidation of the mechanisms involved in cancer progression and therapeutic resistance is critical. FBXW7 is a key regulator of tumor malignant potential, and its substrate MCL1 regulates therapeutic resistance in human mali...

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Pubblicato in:Oncotarget
Autori principali: Ishii, Norihiro, Araki, Kenichiro, Yokobori, Takehiko, Gantumur, Dorgormaa, Yamanaka, Takahiro, Altan, Bolag, Tsukagoshi, Mariko, Igarashi, Takamichi, Watanabe, Akira, Kubo, Norio, Hosouchi, Yasuo, Kuwano, Hiroyuki, Shirabe, Ken
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2017
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5762537/
https://ncbi.nlm.nih.gov/pubmed/29348852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22634
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