Overexpression of karyopherin-α2 in cholangiocarcinoma correlates with poor prognosis and gemcitabine sensitivity via nuclear translocation of DNA repair proteins

Cholangiocarcinoma is a highly malignant tumor, and the development of new therapeutic strategies is critical. Karyopherin-α2 (KPNA2) functions as an adaptor that mediates nucleocytoplasmic transport. Specifically, KPNA2 transports one of the important DNA repair machineries, the MRE11-RAD50-NBS1 (M...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Tsukagoshi, Mariko, Araki, Kenichiro, Yokobori, Takehiko, Altan, Bolag, Suzuki, Hideki, Kubo, Norio, Watanabe, Akira, Ishii, Norihiro, Hosouchi, Yasuo, Nishiyama, Masahiko, Shirabe, Ken, Kuwano, Hiroyuki
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2017
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522057/
https://ncbi.nlm.nih.gov/pubmed/28178675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15020
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