A Mitochondrial-targeted purine-based HSP90 antagonist for leukemia therapy

Reprogramming of mitochondrial functions sustains tumor growth and may provide therapeutic opportunities. Here, we targeted the protein folding environment in mitochondria by coupling a purine-based inhibitor of the molecular chaperone Heat Shock Protein-90 (Hsp90), PU-H71 to the mitochondrial-targe...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Bryant, Kelly G., Chae, Young Chan, Martinez, Rogelio L., Gordon, John C., Elokely, Khaled M., Kossenkov, Andrew V., Grant, Steven, Childers, Wayne E., Abou-Gharbia, Magid, Altieri, Dario C.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5762502/
https://ncbi.nlm.nih.gov/pubmed/29348817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23097
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