Bioanalytical method development and validation of milnacipran in rat plasma by LC–MS/MS detection and its application to a pharmacokinetic study

A simple, sensitive and specific liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was developed for the quantification of milnacipran (MC) in rat plasma by using the liquid–liquid extraction method. Milnacipran-d10 (MCD10) was used as an internal standard (IS). Chromatographic separa...

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Detalhes bibliográficos
Publicado no:J Pharm Anal
Main Authors: Kanala, Kanchanamala, T. Hwisa, Nagiat, Chandu, Babu Rao, Katakam, Prakash, Khagga, Mukkanti, Challa, B.R., Khagga, Bhavyasri
Formato: Artigo
Idioma:Inglês
Publicado em: Xi'an Jiaotong University 2013
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5761007/
https://ncbi.nlm.nih.gov/pubmed/29403859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpha.2013.03.009
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