A validated LC–MS/MS method for the determination of tolterodine and its metabolite in rat plasma and application to pharmacokinetic study

Liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was used for simultaneous quantification of tolterodine and its metabolite 5-hydroxy methyl tolterodine in rat plasma. Tolterodine-d6 and 5-hydroxy methyl tolterodine-d14 were used as internal standards (IS). Chromatographic separation...

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Detalhes bibliográficos
Publicado no:J Pharm Anal
Main Authors: Shaik, Rihana Parveen, Puttagunta, Srinivasa Babu, Kothapalli, Chandrasekhar Bannoth, Awen, Bahlul Zayed Sh., Challa, B.R.
Formato: Artigo
Idioma:Inglês
Publicado em: Xi'an Jiaotong University 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5761003/
https://ncbi.nlm.nih.gov/pubmed/29403860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpha.2013.04.005
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