Method development and validation of Guanfacine in rat plasma by liquid chromatography–tandem mass spectrometry: Application to a pharmacokinetic study

A selective, sensitive and high-throughput liquid chromatography–tandem mass spectrometry (LC–ESI-MS/MS) method has been developed and validated for the quantitation of Guanfacine in rat plasma. Sample clean-up involved liquid–liquid extraction (LLE) and 100 μL of rat plasma was used. YMC BASIC colu...

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Bibliographische Detailangaben
Veröffentlicht in:J Pharm Anal
Hauptverfasser: Goparaju, Suryanarayana Murthy, Nandula, Yadagiri Srinivasa Murthy, Bannoth Kothapalli, Chandrasekher, Challa, B.R., Awen, Bahlul Z.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Xi'an Jiaotong University 2013
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760995/
https://ncbi.nlm.nih.gov/pubmed/29403858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpha.2013.04.006
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