()Integrin α(4)β(7) blockade preferentially impacts CCR6(+) lymphocyte subsets in blood and mucosal tissues of naive rhesus macaques

Infusion of a simianized anti-α(4)β(7) mAb (Rh-α(4)β(7)) just before and following SIV infection protected rhesus macaques from developing AIDS and partially from vaginal SIV acquisition. Recently, short-term treatment with Rh-α(4)β(7) in combination with cART led to prolonged viral suppression afte...

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Publicat a:J Immunol
Autors principals: Calenda, Giulia, Keawvichit, Rassamon, Arrode-Brusés, Géraldine, Pattanapanyasat, Kovit, Frank, Ines, Byrareddy, Siddappa N, Arthos, James, Cicala, Claudia, Grasperge, Brooke, Blanchard, James L., Gettie, Agegnehu, Reimann, Keith A., Ansari, Aftab A, Martinelli, Elena
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760460/
https://ncbi.nlm.nih.gov/pubmed/29196458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1701150
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