Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function

Thyroid hormone (TH) is critical for the maintenance of cellular homeostasis during stress responses, but its role in lung fibrosis is unknown. Here, we found that the activity and expression of iodothyronine deiodinase 2 (DIO2), an enzyme that activates TH, was higher in lungs of patients with idio...

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Publicado en:Nat Med
Main Authors: Yu, Guoying, Tzouvelekis, Argyris, Wang, Rong, Herazo-Maya, Jose D., Ibarra, Gabriel H., Srivastava, Anup, de Castro, Joao Pedro Werneck, DeIuliis, Giuseppe, Ahangari, Farida, Woolard, Tony, Aurelien, Nachelle, e Drigo, Rafael Arrojo, Gan, Ye, Graham, Morven, Liu, Xinran, Homer, Robert J., Scanlan, Thomas S., Mannam, Praveen, Lee, Patty J., Herzog, Erica L., Bianco, Antonio C., Kaminski, Naftali
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760280/
https://ncbi.nlm.nih.gov/pubmed/29200204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4447
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