Loss-of-function of the ciliopathy protein Cc2d2a disorganizes the vesicle fusion machinery at the periciliary membrane and indirectly affects Rab8-trafficking in zebrafish photoreceptors

Ciliopathies are human disorders caused by dysfunction of primary cilia, ubiquitous organelles involved in transduction of environmental signals such as light sensation in photoreceptors. Concentration of signal detection proteins such as opsins in the ciliary membrane is achieved by RabGTPase-regul...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS Genet
Prif Awduron: Ojeda Naharros, Irene, Gesemann, Matthias, Mateos, José M., Barmettler, Gery, Forbes, Austin, Ziegler, Urs, Neuhauss, Stephan C. F., Bachmann-Gagescu, Ruxandra
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2017
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760100/
https://ncbi.nlm.nih.gov/pubmed/29281629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007150
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