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Loss-of-function of the ciliopathy protein Cc2d2a disorganizes the vesicle fusion machinery at the periciliary membrane and indirectly affects Rab8-trafficking in zebrafish photoreceptors

Ciliopathies are human disorders caused by dysfunction of primary cilia, ubiquitous organelles involved in transduction of environmental signals such as light sensation in photoreceptors. Concentration of signal detection proteins such as opsins in the ciliary membrane is achieved by RabGTPase-regul...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:PLoS Genet
मुख्य लेखकों: Ojeda Naharros, Irene, Gesemann, Matthias, Mateos, José M., Barmettler, Gery, Forbes, Austin, Ziegler, Urs, Neuhauss, Stephan C. F., Bachmann-Gagescu, Ruxandra
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Public Library of Science 2017
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760100/
https://ncbi.nlm.nih.gov/pubmed/29281629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007150
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