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Synthesis and biophysical analysis of modified thymine-containing DNA oligonucleotides†

We report the synthesis of a 5-formyl-2′-deoxyuridine (5fU) phosphoramidite and the preparation of oligonucleotides comprising all known, naturally observed eukaryotic thymidine modifications. Biophysical characterization of the synthetic oligonucleotides indicates that 5fU, but not the other T-deri...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Chem Commun (Camb)
Prif Awduron: Kawasaki, F., Murat, P., Li, Z., Santner, T., Balasubramanian, S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5759927/
https://ncbi.nlm.nih.gov/pubmed/28074944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6cc08670e
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