Preferential formation of (5S,6R)-thymine glycol for oligodeoxyribonucleotide synthesis and analysis of drug binding to thymine glycol-containing DNA

We previously reported the chemical synthesis of oligonucleotides containing thymine glycol, a major form of oxidative DNA damage. In the preparation of the phosphoramidite building block, the predominant product of the osmium tetroxide oxidation of protected thymidine was (5R,6S)-thymidine glycol....

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Hauptverfasser: Shimizu, Tatsuhiko, Manabe, Koichiro, Yoshikawa, Shinya, Kawasaki, Yusuke, Iwai, Shigenori
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2006
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1326250/
https://ncbi.nlm.nih.gov/pubmed/16401612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkj443
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