Ablation of transcription factor IRF4 promotes transplant acceptance by driving allogenic CD4(+) T cell dysfunction

CD4(+) T cells orchestrate immune responses and destruction of allogeneic organ transplants, but how this process is regulated on a transcriptional level remains unclear. Here, we demonstrated that interferon regulatory factor 4 (IRF4) was a key transcriptional determinant controlling T cell respons...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Wu, Jie, Zhang, Hedong, Shi, Xiaomin, Xiao, Xiang, Fan, Yihui, Minze, Laurie J., Wang, Jin, Ghobrial, Rafik M., Xia, Jiahong, Sciammas, Roger, Li, Xian C., Chen, Wenhao
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5759774/
https://ncbi.nlm.nih.gov/pubmed/29221730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2017.11.003
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