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Activatable iRGD-based peptide monolith: targeting, internalization, and fluorescence activation for precise tumor imaging

A disulfide-bridged cyclic RGD peptide, named iRGD (internalizing RGD, c(CRGDK/RGPD/EC)), is known to facilitate tumor targeting as well as tissue penetration. After the RGD motif-induced targeting on αv integrins expressed near tumor tissue, iRGD encounters proteolytic cleavage to expose the CendR...

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Detalhes bibliográficos
Publicado no:J Control Release
Main Authors: Cho, Hong-Jun, Lee, Sung-Jin, Park, Sung-Jun, Paik, Chang H., Lee, Sang-Myung, Kim, Sehoon, Lee, Yoon-Sik
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5759763/
https://ncbi.nlm.nih.gov/pubmed/27349354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2016.06.032
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